During the years 1987~1994, spontaneous abortions were studied by analysis chromosomes from chrionic villi. The recurent losses occurred mostly in the first trimester of pregnancy. The fregnancy and the type of anormalies detected among 573
abortuses
are observed by direct and cultured method.
Most case were derived from early abortions before the 13th week of gestation. Of the 573 abortuses analysed, 378(66.0%) had a chromosome anomaly. Trisomy was predominant 241(42.0%), followed by polyploidy 62(10.8%), monosomy X 38(6.6%),
structural
anormaly 26(4.5%), and others 11(1.9%). Trisomy for the chromosome 16 was most prevalent among trisomies. Mean maternal age was gradually increased for trisomies 16, 21 and 22 and it was highest for trisomies 18. However, a gestational age was
not
significant in our present study.
Male to female sex ratio 0.92 and 0.85 for the chromosomally normal and abnormal abortuses respectively. Frequency and type of the chromosome abnormalities may serve as a prerequiste for the investigation of non-chromosomal genetic cause of
pregnancy
wastage.
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